Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 12 Researches
7.2
USERS' SCORE
Moderately Good
Based on 275 Reviews
7.6
Supplement Facts
Serving Size: 2 Capsules
Amount Per Serving
%DV
Red Yeast Rice (Monascus purpureus)
1,200 mg
†
Coenzyme Q10 (Ubiquinone)
100 mg
†
Top Medical Research Studies
9
We delved into the effects of coenzyme Q10 (CoQ10) supplementation on cholesterol levels in adults to determine how it can influence lipid profiles. Through a thorough meta-analysis of fifty randomized controlled trials involving nearly 2800 participants, we explored its potential benefits for reducing cholesterol levels effectively.
Our findings indicated that CoQ10 supplementation significantly lowered levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and triglycerides (TG), while simultaneously increasing high-density lipoprotein cholesterol (HDL-C). This effect was particularly pronounced at a dosage of 400 to 500 mg per day, which was shown to produce the best results in terms of reducing TC.
Overall, the study provided strong evidence that CoQ10 could be a valuable ally in managing high cholesterol, helping to achieve a healthier lipid profile in adults. This research sheds light on a promising dietary supplement that might assist individuals seeking to improve their cholesterol levels effectively.
Our findings indicated that CoQ10 supplementation significantly lowered levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and triglycerides (TG), while simultaneously increasing high-density lipoprotein cholesterol (HDL-C). This effect was particularly pronounced at a dosage of 400 to 500 mg per day, which was shown to produce the best results in terms of reducing TC.
Overall, the study provided strong evidence that CoQ10 could be a valuable ally in managing high cholesterol, helping to achieve a healthier lipid profile in adults. This research sheds light on a promising dietary supplement that might assist individuals seeking to improve their cholesterol levels effectively.
Read More
9
Coenzyme Q10 aids cholesterol management
We explored the impact of coenzyme Q10 on high cholesterol in patients with polycystic ovary syndrome (PCOS) as part of a broader analysis of various nutritional supplements. The study involved a systematic review and network meta-analysis of forty-one randomized controlled trials, including 2,362 patients in total.
Our findings indicated that coenzyme Q10 was notably effective in improving lipid levels, particularly in reducing triglycerides, total cholesterol, and low-density lipoprotein cholesterol (LDL-C). It outperformed other supplements in these areas, suggesting that it may play a crucial role in managing cholesterol levels for individuals with PCOS.
However, it's important to note that while coenzyme Q10 demonstrated efficacy in lipid metabolism, the study did not show significant benefits for other health markers, like high-density lipoprotein cholesterol (HDL-C) or testosterone levels. This points to a need for more in-depth research to fully understand its potential and effectiveness in relation to individual health outcomes within this patient group.
Overall, our analysis suggests coenzyme Q10 could be a viable option for helping to manage high cholesterol in PCOS patients, although further high-quality studies are essential for confirming these results and understanding the broader implications.
Our findings indicated that coenzyme Q10 was notably effective in improving lipid levels, particularly in reducing triglycerides, total cholesterol, and low-density lipoprotein cholesterol (LDL-C). It outperformed other supplements in these areas, suggesting that it may play a crucial role in managing cholesterol levels for individuals with PCOS.
However, it's important to note that while coenzyme Q10 demonstrated efficacy in lipid metabolism, the study did not show significant benefits for other health markers, like high-density lipoprotein cholesterol (HDL-C) or testosterone levels. This points to a need for more in-depth research to fully understand its potential and effectiveness in relation to individual health outcomes within this patient group.
Overall, our analysis suggests coenzyme Q10 could be a viable option for helping to manage high cholesterol in PCOS patients, although further high-quality studies are essential for confirming these results and understanding the broader implications.
Read More
8
CoQ10 improves cholesterol removal functions
We conducted a 24-week study to see how coenzyme Q10 (CoQ10) might help people with high cholesterol levels, specifically by examining its effects on high-density lipoprotein (HDL) function. A total of 101 participants with dyslipidemia were randomly assigned to either a CoQ10 group, which received 120 mg daily, or a placebo group.
We measured how well HDL could help remove cholesterol from the body, known as cholesterol efflux capacity (CEC), along with indicators of inflammation. Our results showed that those taking CoQ10 had a remarkable improvement in how effectively their HDL worked to remove cholesterol and also experienced a reduction in HDL inflammation after 24 weeks.
Interestingly, we noticed that the benefits of CoQ10 appeared to be even stronger in older adults, women, and non-obese individuals. However, CoQ10 didn’t make a significant difference in HDL oxidation levels. Overall, we found that adding CoQ10 to the diet could be a great way to enhance heart health for people struggling with high cholesterol.
We measured how well HDL could help remove cholesterol from the body, known as cholesterol efflux capacity (CEC), along with indicators of inflammation. Our results showed that those taking CoQ10 had a remarkable improvement in how effectively their HDL worked to remove cholesterol and also experienced a reduction in HDL inflammation after 24 weeks.
Interestingly, we noticed that the benefits of CoQ10 appeared to be even stronger in older adults, women, and non-obese individuals. However, CoQ10 didn’t make a significant difference in HDL oxidation levels. Overall, we found that adding CoQ10 to the diet could be a great way to enhance heart health for people struggling with high cholesterol.
Read More
Most Useful Reviews
9
Effective cholesterol treatment
144 people found this helpful
Working drug! It’s important to note that red rice extracts may inhibit the synthesis of coenzyme Q10 (CoQ10), essential for heart health. If you're taking fermented red rice, consider supplementing with 100mg of CoQ10 daily. Unlike pharmaceutical statins, the natural statins in red rice have fewer side effects. This red rice is beneficial, as it contains CoQ10.
Read More
9
Effective alternative
95 people found this helpful
Red Yeast Rice acts as a natural statin. After two months, my tests showed reduced bad cholesterol, improved good cholesterol, and decreased atherogenicity, all without side effects. This has been my best result in managing high cholesterol.
Read More
9
Cholesterol lowering effect
74 people found this helpful
This is great for reducing cholesterol levels.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 12 Researches
7.2
- All Researches
9
Coenzyme Q10 aids cholesterol management
We explored the impact of coenzyme Q10 on high cholesterol in patients with polycystic ovary syndrome (PCOS) as part of a broader analysis of various nutritional supplements. The study involved a systematic review and network meta-analysis of forty-one randomized controlled trials, including 2,362 patients in total.
Our findings indicated that coenzyme Q10 was notably effective in improving lipid levels, particularly in reducing triglycerides, total cholesterol, and low-density lipoprotein cholesterol (LDL-C). It outperformed other supplements in these areas, suggesting that it may play a crucial role in managing cholesterol levels for individuals with PCOS.
However, it's important to note that while coenzyme Q10 demonstrated efficacy in lipid metabolism, the study did not show significant benefits for other health markers, like high-density lipoprotein cholesterol (HDL-C) or testosterone levels. This points to a need for more in-depth research to fully understand its potential and effectiveness in relation to individual health outcomes within this patient group.
Overall, our analysis suggests coenzyme Q10 could be a viable option for helping to manage high cholesterol in PCOS patients, although further high-quality studies are essential for confirming these results and understanding the broader implications.
Our findings indicated that coenzyme Q10 was notably effective in improving lipid levels, particularly in reducing triglycerides, total cholesterol, and low-density lipoprotein cholesterol (LDL-C). It outperformed other supplements in these areas, suggesting that it may play a crucial role in managing cholesterol levels for individuals with PCOS.
However, it's important to note that while coenzyme Q10 demonstrated efficacy in lipid metabolism, the study did not show significant benefits for other health markers, like high-density lipoprotein cholesterol (HDL-C) or testosterone levels. This points to a need for more in-depth research to fully understand its potential and effectiveness in relation to individual health outcomes within this patient group.
Overall, our analysis suggests coenzyme Q10 could be a viable option for helping to manage high cholesterol in PCOS patients, although further high-quality studies are essential for confirming these results and understanding the broader implications.
Read More
9
Combined supplements lower cholesterol
We conducted a study to explore the lipid-lowering effects of a dietary supplement that included coenzyme Q10 as well as other natural extracts. Specifically, we wanted to see how these components could help lower cholesterol levels in individuals with mild hypercholesterolemia. Our study involved 105 participants who had slightly elevated low-density lipoprotein (LDL) cholesterol levels, categorized as mild hypercholesterolemia, and were randomly split into different treatment groups for eight weeks.
One group followed lifestyle changes alone, while the others received either a low or high dosage of monacolin K, a component of red yeast rice, alongside coenzyme Q10, grape seed, and olive leaf extracts. Over the treatment period, we found that both doses of monacolin K significantly reduced LDL cholesterol levels—26.46% with the higher dose and 16.77% with the lower dose.
While we saw some positive results relating to cholesterol reduction, the slight benefit attributed specifically to the coenzyme Q10 was not clearly defined, as it was part of a combination treatment. However, importantly, no severe adverse events were reported, suggesting that this supplement approach is safe for mild high cholesterol management. Overall, our findings suggest that lower-dose monacolin K combined with these natural extracts can be a helpful option for those looking to improve their cholesterol levels.
One group followed lifestyle changes alone, while the others received either a low or high dosage of monacolin K, a component of red yeast rice, alongside coenzyme Q10, grape seed, and olive leaf extracts. Over the treatment period, we found that both doses of monacolin K significantly reduced LDL cholesterol levels—26.46% with the higher dose and 16.77% with the lower dose.
While we saw some positive results relating to cholesterol reduction, the slight benefit attributed specifically to the coenzyme Q10 was not clearly defined, as it was part of a combination treatment. However, importantly, no severe adverse events were reported, suggesting that this supplement approach is safe for mild high cholesterol management. Overall, our findings suggest that lower-dose monacolin K combined with these natural extracts can be a helpful option for those looking to improve their cholesterol levels.
Read More
9
We delved into the effects of coenzyme Q10 (CoQ10) supplementation on cholesterol levels in adults to determine how it can influence lipid profiles. Through a thorough meta-analysis of fifty randomized controlled trials involving nearly 2800 participants, we explored its potential benefits for reducing cholesterol levels effectively.
Our findings indicated that CoQ10 supplementation significantly lowered levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and triglycerides (TG), while simultaneously increasing high-density lipoprotein cholesterol (HDL-C). This effect was particularly pronounced at a dosage of 400 to 500 mg per day, which was shown to produce the best results in terms of reducing TC.
Overall, the study provided strong evidence that CoQ10 could be a valuable ally in managing high cholesterol, helping to achieve a healthier lipid profile in adults. This research sheds light on a promising dietary supplement that might assist individuals seeking to improve their cholesterol levels effectively.
Our findings indicated that CoQ10 supplementation significantly lowered levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and triglycerides (TG), while simultaneously increasing high-density lipoprotein cholesterol (HDL-C). This effect was particularly pronounced at a dosage of 400 to 500 mg per day, which was shown to produce the best results in terms of reducing TC.
Overall, the study provided strong evidence that CoQ10 could be a valuable ally in managing high cholesterol, helping to achieve a healthier lipid profile in adults. This research sheds light on a promising dietary supplement that might assist individuals seeking to improve their cholesterol levels effectively.
Read More
9
We explored the effects of a combination of monacolin K, berberine, and coenzyme Q10 on cholesterol levels in individuals with moderate hypercholesterolemia and cardiovascular risk. This study involved patients divided into two groups: one received the nutraceutical preparation, while the other was given a placebo.
After three months, we observed a notable decrease in LDL cholesterol levels among those who took the nutraceutical, dropping by an impressive 26.1 mg/dL. In contrast, the placebo group showed a slight increase in LDL cholesterol. While non-HDL cholesterol and total cholesterol also decreased in the treatment group, measures like HDL cholesterol, triglycerides, and lipoprotein(a) remained unchanged in both groups.
Importantly, the combination demonstrated good tolerance and a safety profile throughout the study. Therefore, we conclude that coenzyme Q10, as part of this supplement, may be beneficial for lowering cholesterol levels alongside monacolin K and berberine in patients at risk for cardiovascular issues.
After three months, we observed a notable decrease in LDL cholesterol levels among those who took the nutraceutical, dropping by an impressive 26.1 mg/dL. In contrast, the placebo group showed a slight increase in LDL cholesterol. While non-HDL cholesterol and total cholesterol also decreased in the treatment group, measures like HDL cholesterol, triglycerides, and lipoprotein(a) remained unchanged in both groups.
Importantly, the combination demonstrated good tolerance and a safety profile throughout the study. Therefore, we conclude that coenzyme Q10, as part of this supplement, may be beneficial for lowering cholesterol levels alongside monacolin K and berberine in patients at risk for cardiovascular issues.
Read More
8
In this study, we explored how a dietary supplement, which includes coenzyme Q10 among other natural ingredients, affects high cholesterol levels in children and adolescents with moderate to severe hypercholesterolemia. The supplement, Armolipid, was given daily to 84 young participants, aiming to see if it could positively impact their cholesterol levels over time.
Our findings revealed that taking Armolipid led to significant decreases in total cholesterol and low-density lipoprotein cholesterol, which is often referred to as "bad" cholesterol. However, it's important to note that we didn't find any changes in high-density lipoprotein cholesterol, which is the "good" cholesterol, or in other lipid markers such as triglycerides.
Coenzyme Q10 was part of a combination treatment and its specific impact on cholesterol levels was challenging to isolate. While children who had previously used phytosterols saw additional improvements after starting Armolipid, the overall effects of coenzyme Q10 alone remain unclear.
Moving forward, more research involving larger groups of children is necessary to better understand the potential benefits of nutraceuticals like Armolipid in managing cholesterol levels in young people.
Our findings revealed that taking Armolipid led to significant decreases in total cholesterol and low-density lipoprotein cholesterol, which is often referred to as "bad" cholesterol. However, it's important to note that we didn't find any changes in high-density lipoprotein cholesterol, which is the "good" cholesterol, or in other lipid markers such as triglycerides.
Coenzyme Q10 was part of a combination treatment and its specific impact on cholesterol levels was challenging to isolate. While children who had previously used phytosterols saw additional improvements after starting Armolipid, the overall effects of coenzyme Q10 alone remain unclear.
Moving forward, more research involving larger groups of children is necessary to better understand the potential benefits of nutraceuticals like Armolipid in managing cholesterol levels in young people.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 275 Reviews
7.6
- All Reviews
- Positive Reviews
- Negative Reviews
9
Effective cholesterol treatment
144 people found this helpful
Working drug! It’s important to note that red rice extracts may inhibit the synthesis of coenzyme Q10 (CoQ10), essential for heart health. If you're taking fermented red rice, consider supplementing with 100mg of CoQ10 daily. Unlike pharmaceutical statins, the natural statins in red rice have fewer side effects. This red rice is beneficial, as it contains CoQ10.
Read More
9
Effective alternative
95 people found this helpful
Red Yeast Rice acts as a natural statin. After two months, my tests showed reduced bad cholesterol, improved good cholesterol, and decreased atherogenicity, all without side effects. This has been my best result in managing high cholesterol.
Read More
9
Cholesterol lowering effect
74 people found this helpful
This is great for reducing cholesterol levels.
Read More
9
Drastic cholesterol reduction
64 people found this helpful
My cholesterol levels have drastically decreased since I started taking this supplement. When I missed it in hospital for two months, my cholesterol levels shot up again.
Read More
7.5
Normalised cholesterol levels
45 people found this helpful
This product works well! I initially had high cholesterol levels, but after consistent use, my total cholesterol and bad LDL levels improved significantly. It requires ongoing use; hence I will continue to monitor the results.
Read More
Frequently Asked Questions
9
Effective alternative
95 people found this helpful
Red Yeast Rice acts as a natural statin. After two months, my tests showed reduced bad cholesterol, improved good cholesterol, and decreased atherogenicity, all without side effects. This has been my best result in managing high cholesterol.
9
Significant drop
12 people found this helpful
My cholesterol ratio improved from 4.4:1 to 3.2:1, with LDL decreasing by 35% in five weeks after starting Red Yeast Rice from Jarrow. I chose this brand for its Coenzyme Q10 inclusion and affordability. So far, I have not experienced any side effects, and I hope Jarrow maintains its quality.
10
Lowered cholesterol levels
9 people found this helpful
I have struggled with high cholesterol for years, often reaching 7.5-8. After just a month of red yeast rice, it dropped to 5.75! I am thrilled with this outcome! I've taken various vitamins and supplements before, but this result is unprecedented. I'm so happy to find an alternative to statins.
7.5
Normalised cholesterol levels
45 people found this helpful
This product works well! I initially had high cholesterol levels, but after consistent use, my total cholesterol and bad LDL levels improved significantly. It requires ongoing use; hence I will continue to monitor the results.
9
Significant reduction
23 people found this helpful
At 56, I've had high cholesterol for years and struggled with side effects from statins. After replacing garlic extract with red yeast rice, my total cholesterol dropped significantly from 8.39 to 5.6 mmol/l over two months. I plan to continue using red yeast rice.
8.5
Significant reduction
17 people found this helpful
This product greatly lowers high cholesterol! I've used it for two months, resulting in a remarkable drop of 98 points in my total cholesterol. Though my good cholesterol (HDL) dipped a bit, I’m pleased overall.
9
Effective cholesterol treatment
144 people found this helpful
Working drug! It’s important to note that red rice extracts may inhibit the synthesis of coenzyme Q10 (CoQ10), essential for heart health. If you're taking fermented red rice, consider supplementing with 100mg of CoQ10 daily. Unlike pharmaceutical statins, the natural statins in red rice have fewer side effects. This red rice is beneficial, as it contains CoQ10.
7.5
Impressive results
20 people found this helpful
After using red yeast rice alongside fish oil, my HDL cholesterol rose to 67, the best in five years, and my LDL dropped from 133 to 103 after stopping my previous medication due to muscle pain. I'm optimistic for my next test.
9
Natural alternative
10 people found this helpful
I recommend Red Yeast Rice as a natural statin alternative. After taking it with curcumin and evening primrose oil, my cholesterol dropped from 7 to 5.
7.5
Effective treatment
14 people found this helpful
Red rice from Jarrow is beneficial due to its synergist Q10, enhancing its efficacy for high cholesterol and vascular health. After taking Q10, I eliminated the extrasystole I had experienced for years. For those dealing with increased LDL, combining red yeast rice with phytosterols and berberine is recommended. Always consult a doctor if there are kidney or liver issues. I advise everyone to try it, as it can yield a positive outcome.
9
Natural alternative
12 people found this helpful
After consulting my doctor, I discovered I could tackle high cholesterol without statins. My doctor recommended 1200 mg of Red Yeast Rice each evening for 1-2 months, which I found reassuring.
9
We delved into the effects of coenzyme Q10 (CoQ10) supplementation on cholesterol levels in adults to determine how it can influence lipid profiles. Through a thorough meta-analysis of fifty randomized controlled trials involving nearly 2800 participants, we explored its potential benefits for reducing cholesterol levels effectively.
Our findings indicated that CoQ10 supplementation significantly lowered levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and triglycerides (TG), while simultaneously increasing high-density lipoprotein cholesterol (HDL-C). This effect was particularly pronounced at a dosage of 400 to 500 mg per day, which was shown to produce the best results in terms of reducing TC.
Overall, the study provided strong evidence that CoQ10 could be a valuable ally in managing high cholesterol, helping to achieve a healthier lipid profile in adults. This research sheds light on a promising dietary supplement that might assist individuals seeking to improve their cholesterol levels effectively.
Our findings indicated that CoQ10 supplementation significantly lowered levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and triglycerides (TG), while simultaneously increasing high-density lipoprotein cholesterol (HDL-C). This effect was particularly pronounced at a dosage of 400 to 500 mg per day, which was shown to produce the best results in terms of reducing TC.
Overall, the study provided strong evidence that CoQ10 could be a valuable ally in managing high cholesterol, helping to achieve a healthier lipid profile in adults. This research sheds light on a promising dietary supplement that might assist individuals seeking to improve their cholesterol levels effectively.
9
Coenzyme Q10 aids cholesterol management
We explored the impact of coenzyme Q10 on high cholesterol in patients with polycystic ovary syndrome (PCOS) as part of a broader analysis of various nutritional supplements. The study involved a systematic review and network meta-analysis of forty-one randomized controlled trials, including 2,362 patients in total.
Our findings indicated that coenzyme Q10 was notably effective in improving lipid levels, particularly in reducing triglycerides, total cholesterol, and low-density lipoprotein cholesterol (LDL-C). It outperformed other supplements in these areas, suggesting that it may play a crucial role in managing cholesterol levels for individuals with PCOS.
However, it's important to note that while coenzyme Q10 demonstrated efficacy in lipid metabolism, the study did not show significant benefits for other health markers, like high-density lipoprotein cholesterol (HDL-C) or testosterone levels. This points to a need for more in-depth research to fully understand its potential and effectiveness in relation to individual health outcomes within this patient group.
Overall, our analysis suggests coenzyme Q10 could be a viable option for helping to manage high cholesterol in PCOS patients, although further high-quality studies are essential for confirming these results and understanding the broader implications.
Our findings indicated that coenzyme Q10 was notably effective in improving lipid levels, particularly in reducing triglycerides, total cholesterol, and low-density lipoprotein cholesterol (LDL-C). It outperformed other supplements in these areas, suggesting that it may play a crucial role in managing cholesterol levels for individuals with PCOS.
However, it's important to note that while coenzyme Q10 demonstrated efficacy in lipid metabolism, the study did not show significant benefits for other health markers, like high-density lipoprotein cholesterol (HDL-C) or testosterone levels. This points to a need for more in-depth research to fully understand its potential and effectiveness in relation to individual health outcomes within this patient group.
Overall, our analysis suggests coenzyme Q10 could be a viable option for helping to manage high cholesterol in PCOS patients, although further high-quality studies are essential for confirming these results and understanding the broader implications.
4
We conducted a clinical trial to investigate how Coenzyme Q10 (Co-Q10) affects cholesterol levels in women suffering from migraines. Over 12 weeks, 84 females aged 18-50 were split into two groups: one received a daily dose of 400 mg of Co-Q10 while the other received a placebo.
At the end of the study, we found that Co-Q10 supplementation significantly increased levels of high-density lipoprotein (HDL-C), often referred to as "good" cholesterol. This suggests a positive shift in the lipid profile for those taking Co-Q10. However, it did not have a noticeable effect on other cholesterol levels like low-density lipoprotein (LDL), triglycerides, or total cholesterol.
Moreover, the trial revealed an interesting detail: participants experienced a significant reduction in malondialdehyde (MDA) levels, a marker of oxidative stress, highlighting some antioxidant benefits from Co-Q10. It's worth noting that while we saw improvements in HDL-C levels, we did not measure enough change in cholesterol overall to establish Co-Q10 as a definitive treatment for high cholesterol.
At the end of the study, we found that Co-Q10 supplementation significantly increased levels of high-density lipoprotein (HDL-C), often referred to as "good" cholesterol. This suggests a positive shift in the lipid profile for those taking Co-Q10. However, it did not have a noticeable effect on other cholesterol levels like low-density lipoprotein (LDL), triglycerides, or total cholesterol.
Moreover, the trial revealed an interesting detail: participants experienced a significant reduction in malondialdehyde (MDA) levels, a marker of oxidative stress, highlighting some antioxidant benefits from Co-Q10. It's worth noting that while we saw improvements in HDL-C levels, we did not measure enough change in cholesterol overall to establish Co-Q10 as a definitive treatment for high cholesterol.
Our exploration focused on the effects of coenzyme Q10 (CoQ) compared to beeswax alcohol (BWA) in the context of high cholesterol and d-galactose-induced challenges in zebrafish. Throughout a 24-week period, zebrafish exposed to a high-cholesterol and d-galactose diet showed decreased survivability. While BWA demonstrated a beneficial effect on survival, reducing adverse impacts effectively, we observed that CoQ consumption did not significantly improve the survivability of the zebrafish.
Both treatments showed some promise in preventing weight gain associated with the high-cholesterol and d-galactose diets. However, CoQ was less effective in influencing other markers such as blood cholesterol levels and liver health. For example, zebrafish receiving BWA had significant improvements in high-density lipoprotein (HDL) cholesterol and reductions in harmful liver markers compared to those treated with CoQ.
Overall, our findings indicate that while CoQ had some positive influences, its impact was not as strong as that of BWA, particularly regarding blood lipids and cognitive behavior. Therefore, CoQ did not demonstrate the expected significant benefits in managing high cholesterol when tested alongside BWA.
Both treatments showed some promise in preventing weight gain associated with the high-cholesterol and d-galactose diets. However, CoQ was less effective in influencing other markers such as blood cholesterol levels and liver health. For example, zebrafish receiving BWA had significant improvements in high-density lipoprotein (HDL) cholesterol and reductions in harmful liver markers compared to those treated with CoQ.
Overall, our findings indicate that while CoQ had some positive influences, its impact was not as strong as that of BWA, particularly regarding blood lipids and cognitive behavior. Therefore, CoQ did not demonstrate the expected significant benefits in managing high cholesterol when tested alongside BWA.
7
We gathered insights from a comprehensive review that examined how coenzyme Q10 supplementation affects cholesterol levels in people with diabetic nephropathy. The review analyzed findings from multiple randomized controlled trials to assess the effectiveness of this treatment.
The results suggested that coenzyme Q10 supplementation may lead to improvements in several cholesterol markers. Specifically, we observed that there was moderate-quality evidence indicating significant reductions in total cholesterol and low-density lipoprotein cholesterol (LDL-C) levels among patients receiving coenzyme Q10.
However, it's important to note that the evidence was rated as low quality regarding other cholesterol measures like high-density lipoprotein cholesterol (HDL-C), suggesting we should interpret these findings cautiously. Overall, while coenzyme Q10 shows potential benefits for high cholesterol, further research with larger sample sizes may be necessary for confirming these effects with greater certainty.
The results suggested that coenzyme Q10 supplementation may lead to improvements in several cholesterol markers. Specifically, we observed that there was moderate-quality evidence indicating significant reductions in total cholesterol and low-density lipoprotein cholesterol (LDL-C) levels among patients receiving coenzyme Q10.
However, it's important to note that the evidence was rated as low quality regarding other cholesterol measures like high-density lipoprotein cholesterol (HDL-C), suggesting we should interpret these findings cautiously. Overall, while coenzyme Q10 shows potential benefits for high cholesterol, further research with larger sample sizes may be necessary for confirming these effects with greater certainty.
References
- Garoufi A, Papadaki M, Kalogiannis M, Zerva U, Charakida M, et al. Beneficial Effects of a Nutraceutical Combination on Lipid Profiles in Children with Moderate and Severe Hypercholesterolemia. Biomolecules. 2024;14. doi:10.3390/biom14121608
- Cho KH, Lee Y, Bahuguna A, Lee SH, Yang CE, et al. The Consumption of Beeswax Alcohol (BWA, Raydel) Improved Zebrafish Motion and Swimming Endurance by Protecting the Brain and Liver from Oxidative Stress Induced by 24 Weeks of Supplementation with High-Cholesterol and D-Galactose Diets: A Comparative Analysis Between BWA and Coenzyme Q. Antioxidants (Basel). 2024;13. doi:10.3390/antiox13121488
- Zhao M, Tian Z, Zhao D, Kuang H, Liang Y, et al. Associations between dietary coenzyme Q10 intake and lipid profiles in adults: a national cross-sectional study. Front Nutr. 2024;11:1472002. doi:10.3389/fnut.2024.1472002
- Cho KH, Bahuguna A, Lee Y, Lee SH, Kim JE. Twenty-Week Dietary Supplementation with Beeswax Alcohol (BWA; Raydel) Ameliorates High-Cholesterol-Induced Long-Term Dyslipidemia and Organ Damage in Hyperlipidemic Zebrafish in a Dose-Dependent Manner: A Comparative Analysis Between BWA and Coenzyme Q. Pharmaceuticals (Basel). 2024;17. doi:10.3390/ph17111434
- Cai L, Huang Y, Li X, Cao D, Liu F. Effects of dietary intervention on diabetic nephropathy: an umbrella review of systematic reviews and meta-analyses of randomized controlled trials. Front Endocrinol (Lausanne). 2024;15:1385872. doi:10.3389/fendo.2024.1385872
- Hu X, Wang W, Su X, Peng H, Tan Z, et al. Comparison of nutritional supplements in improving glycolipid metabolism and endocrine function in polycystic ovary syndrome: a systematic review and network meta-analysis. PeerJ. 2023;11:e16410. doi:10.7717/peerj.16410
- Dahri M, Sarafan Sadeghi A, Pahlavani N, Nattagh-Eshtivani E, Hashemilar M, et al. The Effects of Coenzyme Q10 Supplementation on Oxidative Status and Lipid Profile in Migraine Patients: A Randomized Double-Blinded Controlled Clinical Trial. Clin Nutr Res. 2023;12:257. doi:10.7762/cnr.2023.12.4.257
- Angelopoulos N, Paparodis RD, Androulakis I, Boniakos A, Argyrakopoulou G, et al. Low Dose Monacolin K Combined with Coenzyme Q10, Grape Seed, and Olive Leaf Extracts Lowers LDL Cholesterol in Patients with Mild Dyslipidemia: A Multicenter, Randomized Controlled Trial. Nutrients. 2023;15. doi:10.3390/nu15122682
- Liu Z, Tian Z, Zhao D, Liang Y, Dai S, et al. Effects of Coenzyme Q10 Supplementation on Lipid Profiles in Adults: A Meta-analysis of Randomized Controlled Trials. J Clin Endocrinol Metab. 2022;108:232. doi:10.1210/clinem/dgac585
- Fahmy MIM, Sayed RH, El-Yamany MF, El-Naggar R, A Eliwa H. Rosuvastatin and co-enzyme Q improve high-fat and high-fructose diet-induced metabolic syndrome in rats via ameliorating inflammatory and oxidative burden. Biomed Pharmacother. 2022;153:113526. doi:10.1016/j.biopha.2022.113526
- Zou J, Tian Z, Zhao Y, Qiu X, Mao Y, et al. Coenzyme Q10 supplementation improves cholesterol efflux capacity and antiinflammatory properties of high-density lipoprotein in Chinese adults with dyslipidemia. Nutrition. 2022;101:111703. doi:10.1016/j.nut.2022.111703
- Martinez-Martin F, Corbella E, Sarasa I, Trias F, Petitbò D, et al. Effects of treatment with monacolin K, berberine and coenzyme Q10 on lipid metabolism in patients with moderate cardiovascular risk. Semergen. 2022;48:403. doi:10.1016/j.semerg.2022.04.005
